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This eBook describes the forward-thinking approach, applying nanotechnology to achieve neuropharmaceutical innovations and aptly discusses the latest research and development trends in innovating Neurotherapeutic Delivery Technologies by leading research groups. The eBook lays down the foundation for breaking barriers in neuro-nanopharmaceutics and the unnerving thought of “Matter over Mind”. The era has arrived where we could well see pharmaceutical products that are truly ‘alive’, superseded with super-robotic feedback devices combined with nanocyborgs that can deliver to the body not only drugs but also a host of materials such as cells, genes, DNA, nerve signals, diagnostic probes, hormones, proteins and peptides in a much more easier manner as we have today with simply swallowing a pill. These revolutionary technologies are described within the later Chapters of this eBook based on a world where neuro-devices implanted into our brains would be fashionable to control our overall moods and performance....

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Updated September 2015. A simple, easy to use therapy for self use at home. Nothing is taken. It's effective and safe having been developed over 20 years and it works on many conditions. The materials used are inexpensive, household items easily obtained. This book contains a free step-by-step guide showing how to use The Therapy. Many have tried it over the years and it's hoped you will as well....

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Key Features: * Effective. * Nothing taken. * Safe. * For any condition. *Developed over 20 years. *No special skill needed. *No side effects. *Simple step-by-step guide. * Inexpensive, easily obtained items used. * Not for use by people under 18 years old or pregnant women. * Only plastic bags come into skin contact. * Everything's reusable except the batteries - unless rechargeable are used. * Use in your own time. * It works! The Therapy is energy based in 3 easy to use parts: 1) Removing energy harmful to health from a person. 2) Transferring energy beneficial to health into a person. 3) Personal Development - new in Version 3. It's new and different, but hopefully you will give it a try and receive substantial benefit. Nothing can be promised but relief should start a few days after using The Therapy Part 1... Good luck, Richard Clark, January 2015, Bedford, UK. ...

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1) The Therapy Part 1: Removing Harmful Energy Part 2: Adding Health Supporting Energy Supplemental Materials: Silica Gel Serotonin Injury & Accident Part 3: Personal Development Introduction Sea Salt Sodium Bicarbonate (Baking Soda) Magnesium Sulphate (Epsom Salts) Potato Starch Yeast Vinegar Wheat Bran Corn or Maize Rice Millet Oats Soya or Soybeans Sugar More on Personal Development Afterword 2) The Problem of Illness A) The Burning of Fossil Fuels B) Insect Life, Material, Energy & Bites - Clear Fluid - Insect Material and Energy - Insect Life - The Used Energy Residue of Artificial Heat and Cold - Conditions that Start in the Womb - Cell Division - Rheumatoid Arthritis - Energy Packets - Cancer C) Bacteria D) The Energy of Fungal Infections Conditions Involving Fossil Fuel Energy and Insect Bites General Conditions Clear Fluid Vital Energy Harmful Electrical Energy The Bodies Electrical Energy Water in the Body Skin Conditions Other Conditions Viral, Bacterial and Fungal Infections Life Supporting Energy 3) The Problem of Health 4) How The Therapy works The Therapy, It...

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A non-religious and non-spiritual version of the classic Twelve Steps of Alcoholic Anonymous and Al-Anon.

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Tuberculosis (TB) is caused by members of the Mycobacterium tuberculosis (M. tuberculosis) complex, which include: M. tuberculosis, M. bovis, M. bovis BCG, M. africanum, M. microti, M. canetti, M. pinipedii, M. caprae and M. mungi [1]. Other Tuberculosise that may infect humans include: M. leprae, M. avium, M. intracellulare and M. scrofulaceum. M. tuberculosis is an aerobic, non-spore-forming, non-motile bacillus. It belongs to the family Tuberculosisceae [2]. M. tuberculosis is pathogenic for humans while M. bovis is usually pathogenic for animals. Once infected, active disease develops in about 10% of cases, usually within 1 - 2 years after exposure. The remaining individuals enter into a state of latency which can reactivate at a later stage particularly if the individual becomes immunocompromised [3]. Active TB is predominantly pulmonary in nature and develops in 59% of cases, while extrapulmonary TB occurs in the rest. Latent TB infection has no clinical manifestations and is not contagious, but can reactivate at a later stage, particularly if the immunity of the host decreases significantly [3,4]. Immunocompromised patients ...

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This book, ‘INTERNAL ARMED CONFLICT: International Legal Framework Concerning Women and Children’, seeks to assess the application of customs and laws governing the internal armed conflict. This handbook presents an overview of various international instruments for the protection of women and children. By preventing the transcending of conflicts into brutality and savagery, the law of armed conflict aids the restoration of peace and the resumption of friendly relations. Women and children are opined to be accorded special respect and protection. Most of today’s conflicts take place within states. They have tragic feature in common, women and children suffer their impact disproportionately. The concept of children’s rights has widened and the international mandate to reinforce the rights of the child has grown over the years, with the mounting evidence of hardship and abuse suffered by the children. The principles outlined in the international human rights framework apply both to children and adults. Children and women are mentioned explicitly in many of the human rights instruments; standards are specifically modified o...

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Why is this work so important? Most "modern" Anglo-Saxon authors cite Brodmann's 1909 work "Die Lokalisationslehre" for any reference to localization in the neocortex. However, during my own studies I found that sadly lacking in detail. For example, it contains only about 12 pages dedicated to the human neocortex. Von Economo and Koskinas apparently also felt this lack, as they wrote "Unfortunately, BRODMANN has given no description of the architectonics of this area, but has only listed the borders of his Areae, without one word about the cellular structure, and thus without having justified his tiling." (p. 693). Their own work is even today by far the most detailed cytoarchitectonic description of human neocortical areas, their features and their borders. The authors also include extensive discussions of all prior research on each area, revealing that the "old masters" knew very much which in the intervening decades has been forgotten and sometimes "re-discovered."...

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"If we submit this book to the public after a laborious, long work of one dozen years - the work was begun by Professor V. ECONOMO in the year 1912; 1919 Dr. KOSKINAS entered into the cooperation - this does not happen with the joyful satisfaction of having created something consummate. Only an artist can possess this feeling of having created something entirely of himself. Each scientific work however - however much new it brings - rests on the groundwork of whole generations and can be tested only through the work of later generations. In a certain sense those few researchers are enviable who with increased self-esteem overlook this fact, and feel the beginning and end of all of their knowledge is a product of their own examinations. However, every scientific work is always only a part of a total, only a stone; however, sometimes a cornerstone of that wall, which constantly builds the intellectual culture in the course of civilizations to protect itself from the enmity of superstition, ignorance and primitive instincts."...

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General part. Chapter 1. Introductory remarks. Chapter 2. General remarks on the cortex and its neurons. Chapter 3. Structure and development of the cortical lamellae. Chapter 4. Details of the composition and meaning of the lamellar cortex structure. Chapter 5. Area division of the cortex. Chapter 6. Methodology. Specific part. Description the individual areas of the cerebral cortex. Chapter 7. The frontal lobe. (Lobus frontalis) Chapter 8. Lobus limbicus superior. Chapter 9. Lobus insulae. Chapter 10. Lobus parietalis. Chapter 11. Lobus occipitalis. Chapter 12. Lobus temporalis. Chapter 13. Lobus limbicus inferior. Chapter 14. Final remarks....

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A manual how to make ointments with a list of oils and effective recipes. all can be easily made at home and will help you to stay healthy. Natural cosmetic which doesn't contain any chemicals and biodegradable herbal soaps....

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Hepatitis C Virus (HCV) was found as the causative agent of the Non-A, Non-B Hepatitis (NANBH) in 1989. HCV is an enveloped RNA virus that could be classified into six genotypes. The major host cell supporting HCV replication is the human hepatocyte. HCV is primarily transmitted by exposure to contaminated blood. HCV exists in host blood as quasispecies, a population of dynamic strains closely related to each other. Hepatitis C patients may have decreased appetite, abdominal pain, jaundice, fatigue and flu-like symptoms, or could be asymptomatic. Acute infection refers to the first six months of HCV infection, while more than 75% of patients develop chronic Hepatitis in the natural course of HCV infection. The interactions between host immune responses and virus immune evasion determine the outcome of HCV infection. The base of the current standard therapy of HCV is pegylated interferon and ribavirin, the usage of which is restricted due to its side effects. No HCV vaccine is currently available in clinics. However, recent research has shown that a single strain of HCV could elicit broad cross-neutralizing antibodies against all kno...

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The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. L-tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive nitrogen intermediates to form 3-nitrotyrosine (3-NT). 3-NT formation is also catalyzed by a class of peroxidases utilizing nitrite and hydrogen peroxide as substrates. Evidence supports the formation of 3-NT in vivo in diverse pathologic conditions and 3-NT is thought to be a relatively specific marker of oxidative damage. The formation of nitrotyrosine represents a specific peroxynitrite-mediated protein modification; thus, detection of nitrotyrosine in proteins is considered as a biomarker for endogenous peroxynitrite activity. Formation of tyrosine nitrated proteins is considered to be a post-translational modification with important pathophysiological consequences and is one of the markers of nitrosative stress that have been reported in neurodegeneration, inflammatory and other pathological conditions....

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One of the basic research objectives of the present monograph is to update multidisciplinary specialists on contemporary instrumental and analytical means and methods of automatic polysystemic sanogenetic monitoring. The unique advantage of this monitoring lies in not only information capacity of dynamic criteria registered, but also its ability to automate measurement and indication procedures and to ensure simultaneous operation and development of technical facilities. Substantuation of the sanogenetic theory, creation of automatic examination facilities for individual sanogenesis and large-scale approbation of these methods in school, sport and environment medicine required cooperation of specialists from many scientifi c fi elds....

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En la redacción de un blog, que inició muy genérico, sin presupuesto y que tampoco generaba ingresos, empezamos a notar una similitud entre algunos tópicos de medicina y biología, y otros de negocios. Sin ánimos de usarlo como una estrategia de mercadeo, encontramos que la investigación es como el sexo, porque hay que hacerlo para entenderlo, el desarrollo es como un juego, porque uno debe cambiar las variables hasta encontrar la combinación correcta, y la innovación es como el punk rock, porque no debe temer al fracaso, debe ser tangencial y no debe tener miedo de retar a lo ortodoxo....

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De acuerdo con la Contraloría General de la República de Panamá, en el 2011 el pais contaba con un total de 5,551 médicos, 4,744 enfermeras, 1,171 laboratoristas clínicos, 1,114 odontólogos, 757 farmacéuticos, 257 fisioterapistas y 153 nutricionistas en ejercicio en instituciones públicas de salud.(1) No hay cifras sobre la cantidad de profesionales sanitarios en ejercicio privado exclusivo, pero hay 663 clínicas y hospitales, 250 farmacias y 124 laboratorios clínicos privados, aproximadamente, en todo el país. En Panamá, la mayoría de los profesionales de la salud se ve forzado a trabajar en las prácticas institucional y privada para solventar los gastos propios de una agonizante clase media y de un proceso académico en inflación. Este último fenómero lo comparten la mayor parte de los países del mundo occidental. Nuestro interés de investigar sobre el aspecto empresarial de la atención sanitaria provino de la experiencia al concebir, emprender y operar un pequeño laboratorio de patología en la provincia de Chiriquí, una región predominantemente rural de la República de Panamá, adyacente a Costa Rica. Iniciamos en julio del...

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Primera parte 1) Leyes de Loeb 2) Navaja de Occam 3) Adyacente posible 4) Crecimiento -versus- Desarrollo 5) Percepción estética 6) La investigación es como el sexo Segunda parte 7) Juegos que no son juego 8) Poder 9) ¡Hágalo usted mismo! 10) 10,000 horas 11) Nuestras redes 12) El secreto de vivir es compartir 13) Ensuciarse las manos Tercera parte 14) La paradoja sanitaria 15) Innovación 16) Salud 2.0 17) Incompetentes e insoportables 18) Equipos innovadores, no genios solitarios 19) Serendipia y sincronicidad Cuarta parte 20) Arenas movedizas 21) Alma corporativa 22) La confianza es un bien 23) Grandes recompensas, grandes errores 24) Cisnes negros ...

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Each chapter in this eBook is meant to provide pertinent clinical, diagnostic, and management strategies when caring for critically ill patients. The chapters are relatively brief, clinically relevant and evidence-based according to currently accepted literature. References are provided for readers wanting to explore subjects in greater detail. I have edited and revised the content and style of each chapter so as to unify the voice of the entire text....

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Non-infectious uveitis comprehends a heterogeneous group of intraocular inflammatory diseases that arise without a known infectious trigger. This complex group of disorders is often associated with immunological responses to retinal proteins, as experimental models of autoimmune uveoretinitis have shown. Herein we are going to discuss the biology of ocular immune privilege and the immunologic mechanisms that sustain non-infectious uveitis pathophysiology....

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This eBook is an Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. However, users who aim to disseminate and distribute copies of this book as a whole must not seek monetary compensation for such service (excluded OMICS Group representatives and agreed collaborations). After this work has been published by OMICS Group, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source....