Add to Book Shelf
Flag as Inappropriate
Email this Book

Advances in Protein Chemistry

By Ashraf, Chulam, Dr.

Click here to view

Book Id: WPLBN0003468664
Format Type: PDF eBook:
File Size: 14.80 MB
Reproduction Date: 1/1/2014

Title: Advances in Protein Chemistry  
Author: Ashraf, Chulam, Dr.
Volume:
Language: English
Subject: Non Fiction, Medicine, Protein chemistry
Collections: Authors Community, Medicine
Historic
Publication Date:
2014
Publisher: OMICS Group
Member Page: OMICS eBooks

Citation

APA MLA Chicago

Chulam Ashraf, B. D. (2014). Advances in Protein Chemistry. Retrieved from http://gutenberg.cc/


Description
The free radical-mediated damage to proteins results in the modification of amino acid residues, cross-linking of side chains and fragmentation. L-tyrosine and protein bound tyrosine are prone to attack by various mediators and reactive nitrogen intermediates to form 3-nitrotyrosine (3-NT). 3-NT formation is also catalyzed by a class of peroxidases utilizing nitrite and hydrogen peroxide as substrates. Evidence supports the formation of 3-NT in vivo in diverse pathologic conditions and 3-NT is thought to be a relatively specific marker of oxidative damage. The formation of nitrotyrosine represents a specific peroxynitrite-mediated protein modification; thus, detection of nitrotyrosine in proteins is considered as a biomarker for endogenous peroxynitrite activity. Formation of tyrosine nitrated proteins is considered to be a post-translational modification with important pathophysiological consequences and is one of the markers of nitrosative stress that have been reported in neurodegeneration, inflammatory and other pathological conditions.

 
 



Copyright © World Library Foundation. All rights reserved. eBooks from Project Gutenberg are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.