Opportunities at the Intersection of Nanoscience, Biology and Computation

By Williams, Ellen

Book Id: WPLBN0000020000
Format Type: PDF eBook:
File Size: 5.12 MB
Reproduction Date: 2008

Title:	Opportunities at the Intersection of Nanoscience, Biology and Computation
Author:	Williams, Ellen
Volume:
Language:	English
Subject:	Government publications, Legislation., Government Printing Office (U.S.)
Collections:	Government Library Collection
Historic Publication Date:
Publisher:	Government Printing Office


Citation APA MLA Chicago Williams, B. E. (n.d.). Opportunities at the Intersection of Nanoscience, Biology and Computation. Retrieved from http://gutenberg.cc/

Excerpt
Excerpt: Research capabilities in Nanoscience, molecular biology and computation have advanced to the point where it is possible to define research activities in which the development of nano-bio systems will support major DOE science goals. Specifically, we identify two major long term research goals which can motivate research at the intersection of nanoscience and biology: // 1) Development of biological-systems-control for bioremediation, carbon dioxide sequestration and tailored biomaterials fabrication. // 2) Development of artificial nanosystems with biomimetic...

Table of Contents
Contents 1 EXECUTIVE SUMMARY 1 2 INTRODUCTION 3 NANOSCALE COMPONENTS AND SENSING 7 3.1 Questions for cellular function at the nanoscale level . . . . . . 9 3.2 Nanoscale Tags for Cellular Interiors . . . . . . . . . . . . . . 12 3.2.1 Optical sensing with functionalized quantum dots . . . 13 3.2.2 Other nano-particle probes . . . . . . : . . . . . . . . . 15 3.2.3 Magnetic Nanoparticles . . . . . . . . . . . . . . . . . . 17 3.3 Sensing with Electrical Transduction . . . . . . . . . . . . . . 18 3.3.1 Nanowire sensors . . . . . . . . . . . . . . . . . . . . . 18 3.3.2 Nanotube sensors . . . . . . . . . . . . . . . . . . . . . 19 3.4 Nanopores and Nanoporous Membranes . . . . . . . . . . . . . 22 3.4.1 Nanoporous membranes . . . . . . . . . . . . . . . . . 22 3.4.2 Single nanopores . . . . . . . . . . . . . . . . . . . . . 24 3.5 Membranes . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 3.6 SPM Imaging and Manipulation of Biological Systems . . . . . 32 3.7 Nanocomponents Synopsis . . . . . . . . . . . . . . . . . . . . 33 4 ASSEMBLY CHALLENGE 39 4.1 Chemical Linkages for Nanoassembly . . . . . . . . . . . . . . 39 4.2 Biological Nano-components . . . . . . . . . . . . . . . . . . . 45 4.2.1 Artificial photosynthetic system . . . . . . . . . . . . . 46 4.3 Systems Modeling . . . . . . . . . . . . . . . . . . . . . . . . . 50 4.3.1 Rate Equation Modeling . . . . . . . . . . . . . . . . . 51 4.3.2 High throughput data-bases . . . . . . . . . . . . . . . 55 4.3.3 Bio-engineering Modeling . . . . . . . . . . . . . . . . 58 4.4 Computational Issues for Bio-Nano Assemblies . . . . . . . . . 62 5 MOLECULAR MODELING CHALLENGES 67 5.1 Approaches and Goals in Molecular Computation . . . . . . . . 68 5.1.1 Membrane proteins: function and crystallization . . . . 70 5.1.2 Illustration of computational application: molecular docking . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1 5.2 K+ ion Channel Membrane Protein . . . . . . . . . . . . . . . 75