Health Organisation, Malaria Comission; World Health Organization : Organisation Mondiale de la Sante; Serie de Monographies, Issue No. 81. 948: Report on the Merieux Foundation/O Meeting on Immunological Methods in Mmariology

By World Health Organization

Book Id: WPLBN0000027364
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Reproduction Date: 2005

Title:	Health Organisation, Malaria Comission; World Health Organization : Organisation Mondiale de la Sante; Serie de Monographies, Issue No. 81. 948: Report on the Merieux Foundation/O Meeting on Immunological Methods in Mmariology
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Health Organization, B. W. (n.d.). Health Organisation, Malaria Comission; World Health Organization : Organisation Mondiale de la Sante; Serie de Monographies, Issue No. 81. 948. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
The issue of this document does not constitute formal publication . It should not be reviewed. abstracted or quoted without the agreement of the World Health Organization . Authors alone are responsible for views expressed in signed articles .

Table of Contents
CONTENTS Page 2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Methodology. 3 . . . . . . . . . . . . . . . . . . . 1.1 Current status of iuimunodiagnostic tests 3 1.1.1 Indirect immunofluorescent (IIF) test . . . . . . . . . . . . . . . . . 3 1.1.2 Gel diffusion and electrophoresis . . . . . . . . . . . . . . . . . . . 3 1.1.3 Passive or indirect haemagglutination (IHA) test . . . . . . . . . . . 4 1.1.4 Enzyme-iuimunoassay (EIA) and radioimmunoassay (RIA) . . . . . . . . . . . 4 1.2 Techniques not yet applied in the field of malaria . . . . . . . . . . . . . . 5 1.2.1 Thin-layer immunoassay (TIA) and indium-coated slide technique . . . . 5 . . . . . . . . . . . . . . . . . . . . . . . . . . 1.2.2 Latex agglutination 5 1.2.3 Fluoroimmunoassay (FIAX~) . . . . . . . . . . . . . . . . . . . . . . . 5 1.3 New techniques insufficiently developed or refined for malaria immunodiagnos is . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 . . . . . . . . . . . . . . . . . . . . . 1.3.1 Miniaturization of techniques 5 1.3.2 Lectins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.3.3 Fluorogenic substances . . . . . . . . . . . . . . . . . . . . . . . . 6 1.4 Potential application of monoclonal antibodies . . . . . . . . . . . . . . . . 6 . . . . . . 1.5 Recombinant DNA techniques for the production of malarial antigens 6 1.5.1 Plasmodia1 genome libraries . . . . . . . . . . . . . . . . . . . . . . 6 1.5.2 Cloning of DNA . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2 . Standardization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.1 Methods . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 . 7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 Antigen 2.3 Reference sera . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.4 Equipment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.5 Recommendations 8 3 . Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.1 Indications . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 3.1.1 Areaswithendemicmalaria . . . . . . . . . . . . . . . . . . . . . . 8 3.1.2 Areas with high malariogenic potential where malaria has been eradicated . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3.1.3 Areas free from malaria with a low malariogenic potential . . . . . . . 9