World Health Organization : Year 1985-86 ; (Tdr) the Special Programme for Research and Training in Tropical Diseases Chemal 3Rd Review 85.3: Scientific Working Group on TBE Chemotherapy of Malaria Third Programme Review

By M. Aikawa, Prof., N. Anand, Prof., And A. Brossi, Dr.

Book Id: WPLBN0000056378
Format Type: PDF eBook:
File Size: 0.9 MB
Reproduction Date: 2005

Title:	World Health Organization : Year 1985-86 ; (Tdr) the Special Programme for Research and Training in Tropical Diseases Chemal 3Rd Review 85.3: Scientific Working Group on TBE Chemotherapy of Malaria Third Programme Review
Author:	M. Aikawa, Prof., N. Anand, Prof., And A. Brossi, Dr.
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Aikawa, Prof., N. Anand, Prof., And A. Brossi, Dr, B. M. (n.d.). World Health Organization : Year 1985-86 ; (Tdr) the Special Programme for Research and Training in Tropical Diseases Chemal 3Rd Review 85.3. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
INTRODUCTION The S c i e n t i f i c Working Group (SWG) on the Chemotherapy of Malaria C l l M of the UNDP/WORLD BANK/WHO Special Programme f o r Research and Tralning in Tropical Diseases (TDR) met i n Geneva, Switzerland, on 3-5 June 1985 to review the CHEMAL programme and make recommendations on future d i r e c t i o n s f o r research. CHEMAL's research programme was established in 1975. The following brief review of t h e t o p i c s of its SWG meetings r e f l e c t s some of the major research d i r e c t i o n s since 1978, when the second SWG reviewed the o b j e c t i v e s and progress of the CHEMAL programme, i d e n t i f i e d problems i n i t s implementation and determined i t s future d i r e c t i o n (1). In October 1980, the t h i r d SWG focused on t i s s u e schizontocides (2). An SWG Section Meeting in May 1981 reported on the development of mefloquine (3) and the f o u r t h SWG i n October 1981 considered the development of qinghaosu and its d e r i v a t i v e s as a n t i - malarial drugs (&). The proceedings of an SWG meeting on the modern design of a n t i m a l a r i a l drugs, held in Bechesda, MD, USA, in June 1982, were published i n 1983 (5). A second publication comprising papers on the pharmacokinetics, mctabolism, t o x i c i t y and a c t i v i t y of primaquine, presented a t an SWG meeting hel,d in Geneva i n February 198L. i s i n press (6).

Table of Contents
CONTENTS 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 i 2. ADVANCES IN THE PAST DECADE . . . . . . . . . . . . . . . . . . . . 4 2.1 Experimental Parasitology . . . . . . . . . . . . . . . . . . . 4 2.1.1 Parasite structure and organelle function. . . . . . . . 4 2.1.2 Biochemistry . . . . . . . . . . . . . . . . . . . . . . 5 2.1.2.1 Glycolysie . . . . . . . . . . . . . . . . . . 5 2.1.2.2 Pentose phosphate pathway . . . . . . . . . . . . 5 2.1.2.3 Oxygen utilization and electron transport . . . . 5 2.1.2.4 Lipids . . . . . . . . . . . . . . . . . . . . . 5 2.1.2.5 themoglobin uCilizat~on and pigment formation . . 6 2.1.2.6 DNA synthesis . . . . . . . . . . . . . . . . . . 6 2.1.2.7 Purines and pyrimidines . . . . . . . . . . . . . 6 2.1.2.8 Histidine-rich protein . . . . . . . . . . . . . 7 2.1.3 Modes of drug action and mechanisms of resistance 7 . . . i! 2.1.3.1 Antifolatea . . . . . . . . . . . . . . . . . . . 7 2.1.3.2 8-Aminoquinolines and naphthoquinones . . . . . . 8 2.1.3.3 4-Aminoquinolines and related blood schitontocides . . . . . . . . . . . . . . . . 8 2.1.3.4 Antibiotics . . . . . . . . . . . . . . . . . . . 10 2.1.3.5 Artemisinine (qinghaosu) . . . . . . . . . . . . 10 2.1.4 In vitro tests for drug activity against malaria parasites . . . . . . . . . . . . . . . . . . 11 2.1.4.1 Asexual erythrocytic parasites . . . . . . . . . 11 2.1.A.2 Exoeryrhrocytic parasites . . . . . . . . . . . . 11 2.1.4.3 Gametocytes . . . . . . . . . . . . . . . . . . . 11 2.1.5 Parasite genetics . . . . . . . . . . . . . . . . . . . 12 I 2.1.6 DNA probes: Potential applications to 1 malaria diagnosis . . . . . . . . . . . . . . . . . 1