Achieving Results through Commitment and Collaboration

By Jones, James J.

Book Id: WPLBN0000087466
Format Type: PDF eBook:
File Size: 2.42 MB
Reproduction Date: 2007

Title:	Achieving Results through Commitment and Collaboration
Author:	Jones, James J.
Volume:
Language:	English
Subject:	Ecology, Natural resource issues, Environemtal protection
Collections:	Environmental Awareness Library Collection
Historic Publication Date:
Publisher:	United States Environmental Protection Agency


Citation APA MLA Chicago J. Jone, B. J. (n.d.). Achieving Results through Commitment and Collaboration. Retrieved from http://gutenberg.cc/

Description
Excerpt: Providing Pesticide Training to Regulators In an effort to fulfill training needs of regional, state, and tribal regulators on pesticide regulatory issues, OPP hosted five Pesticide Regulatory Education Program (PREP) courses in FY 2003. Representatives from more than 23 states attended the courses on the reregistration and worker protection programs, bioengineered crops and invasive species, West Nile virus, homeland security, and state FIFRA laboratory issues.

Table of Contents
CONTENTS —TOXICOLOGICAL REVIEW for 1,2-DIBROMOETHANE (CAS No. 106-93-4) LIST OF TABLES.............................................................v LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii FOREWORD . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .viii AUTHORS, CONTRIBUTORS, AND REVIEWERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ix 1. INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 2. CHEMICAL AND PHYSICAL PROPERTIES RELEVANT TO ASSESSMENT . . . . . . . . 3 3. TOXICOKINETICS RELEVANT TO ASSESSMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.1. ABSORPTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.2. METABOLISM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3.3. DISTRIBUTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3.4. EXCRETION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3.5. PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS . . . . 11 4. HAZARD IDENTIFICATION................................................13 4.1. STUDIES IN HUMANS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 4.1.1. LETHALITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 4.1.2. REPRODUCTIVE TOXICITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 4.1.3. CANCER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 4.2. PRECHRONIC AND CHRONIC STUDIES AND CANCER BIOASSAYS IN ANIMALS......................................................20 4.2.1. CARCINOGENICITY BIOASSAYS AND CHRONIC ORAL STUDIES.................................................20 4.2.2. CARCINOGENICITY BIOASSAY AND CHRONIC INHALATION STUDIES.................................................25 4.2.3. SUBCHRONIC INHALATION STUDIES . . . . . . . . . . . . . . . . . . . . . . . 28 4.2.4. OTHER STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 4.3. REPRODUCTIVE AND DEVELOPMENTAL STUDIES IN ANIMALS - ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 4.3.1. INHALATION STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 4.3.2 ORAL STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 4.4. OTHER STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 4.4.1. REPRODUCTIVE/DEVELOPMENTAL . . . . . . . . . . . . . . . . . . . . . . . . 43 4.4.2. DEVELOPMENTAL NEUROTOXICITY . . . . . . . . . . . . . . . . . . . . . . . 45 4.4.3. GENOTOXICITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 4.4.4. ACUTE TOXICITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 49 4.5. SYNTHESIS AND EVALUATION OF MAJOR NONCANCER EFFECTS AND MODE OF ACTION – ORAL AND INHALATION . . . . . . . . . . . . . . . . . . . . 50