World Health Organization : Organisation Mondiale de la Sante ; Serie de Monographies, Volume Number 27, (1Ed): Chemotherapy of Malaria

By Gordon Covell, M. D.

Book Id: WPLBN0000102309
Format Type: PDF eBook
File Size: 4.4 MB
Reproduction Date: 2005

Title:	World Health Organization : Organisation Mondiale de la Sante ; Serie de Monographies, Volume Number 27, (1Ed): Chemotherapy of Malaria
Author:	Gordon Covell, M. D.
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago M. D, G. C. (n.d.). World Health Organization : Organisation Mondiale de la Sante ; Serie de Monographies, Volume Number 27, (1Ed). Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
INTRODUCTION At its fourth session, held in Kampala, Uganda, in December 1950, the Expert Committee on Malaria of the World Health Organization expressed the opinion that it was desirable to bring together for the benefit of the medical profession factual information on the properties of antimalarial drugs, and advised the appointment of a drafting committee to undertake the task. In accordance with this recommendation, a committee was appointed with the following members : Sir Gordon Cove11 (Chairman), Dr. G. Robert Coatney , Dr. John W. Field, and Lieutenant-Colonel Jaswant Singh.

Table of Contents
CONTENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Introduction 7 Chapter 1 . Definition of terns and historical review . . . . . . . 9 . . . . . . . . . . . . . . . . . . . . . . . . . Definition of terms 9 . . . . . . . . . . . . . . . . . . . . . . . . . . . Historical review 10 . . . . . . . . Chapter 2 . The rationale of malaria chemotherapy 15 . . . . . . . . . . . . . . . . . . . . . . . . The chemical approach 15 . . . . . . . . . . . . . . . . . . . . . . . The biological approach 23 . . . . . . . . Chapter 3 . Individual compounds in common use 32 Quinine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 . . . . . . . . . . . . . . . . Primaquine and other 8-aminoquinolines 37 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Mepacrine 39 . . . . . . . . . . . . . . . Chloroquine and other Caminoquinolines 43 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Proguanil 46 . . . . . . . . . . . . . . . . . . . . . . . . . . . . Pyrimethamine 51 . . . . . . . . . . . . . . . Chapter 4 . Drug-resistance in malaria 54 . . . . . . . . . . . . . Resistance to the common antimalarial drugs 57 . . . . . . . . . . . . . . . . . . . . . . . . . Proguanil-resistance 59 . . . . . . . . . . . . . . . . . . . . . . . . . . . Cross-resistance 64 . . . . . . . . . . . . . . . Origin and mechanism of drug-resistance 65 . . . . . . . . . . . . . . . . . . . . . . . . . . . . Commentary 67 . . . . . . . . Chapter 5 . The clinical use of antimalarial drugs 69 . . . . . . . . . . . . . . . . . . The aims of malaria chemotherapy 70 The confusions of dosage . . . . . . . . . . . . . . . . . . . . . . . 72 . . . . . . . . . . . . . . . . . . . . . . . . . The malaria patient 74 . . . . . . . . . . . . . . . . . . . . . . . The symptomless carrier 85 Individual drug prophylaxis . . . . . . . . . . . . . . . . . . . . . . 86 . . . . . . . . . . . . . . . . . . . . . . Collective drug prophylaxis 89