Guidelines for Mutagenicity Risk Assessment

By Environmental Protection Agency

Book Id: WPLBN0000126495
Format Type: PDF eBook
File Size: 0.3 MB
Reproduction Date: 2007

Title:	Guidelines for Mutagenicity Risk Assessment
Author:	Environmental Protection Agency
Volume:
Language:	English
Subject:	Ecology, Natural resource issues, Environemtal protection
Collections:	Environmental Awareness Library Collection
Historic Publication Date:
Publisher:	United States Environmental Protection Agency


Citation APA MLA Chicago Agency, E. P. (n.d.). Guidelines for Mutagenicity Risk Assessment. Retrieved from http://gutenberg.cc/

Description
Excerpt: DISCLAIMER This document has been reviewed in accordance with U.S. Environmental Protection Agency policy and approved for publication. Mention of trade names or commercial products does not constitute endorsement or recommendation for use. Note: This document represents the final guidelines. A number of editorial corrections have been made during conversion and subsequent proofreading to ensure the accuracy of this publication.

Table of Contents
CONTENTS Federal Register Preamble . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . iv Part A: Guidelines for Mutagenicity Risk Assessment 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1. Concepts Relating to Heritable Mutagenic Risk . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2. Test Systems . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. Qualitative Assessment (Hazard Identification) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.1. Mutagenic Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2.2. Chemical Interactions in the Mammalian Gonad . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3. Weight-of-Evidence Determination . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 3. Quantitative Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3.1. Dose Response . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3.2. Exposure Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 3.3. Risk Characterization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 4. References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Part B: Response to Public and Science Advisory Board Comments . . . . . . . . . . . . . . . . . 17