Using Global Genomic Expression Technology to Create a Knowledge Base for Protecting Human Health

By Olden, Kenneth, Ph. D.

Book Id: WPLBN0000147594
Format Type: PDF eBook:
File Size: 0.8 MB
Reproduction Date: 2005

Title:	Using Global Genomic Expression Technology to Create a Knowledge Base for Protecting Human Health
Author:	Olden, Kenneth, Ph. D.
Volume:
Language:	English
Subject:	Health., Medical research, Medical reports
Collections:	Medical Library Collection
Historic Publication Date:
Publisher:	Centers for Disease Control and Prevention


Citation APA MLA Chicago Olden, Ph. D, B. K. (n.d.). Using Global Genomic Expression Technology to Create a Knowledge Base for Protecting Human Health. Retrieved from http://gutenberg.cc/

Excerpt
The latter part of the 20th century was marked by a series of rapid advances in genomics-based biotechnology. One such advance was the emergence of the field of toxicogenomics — the collection, interpretation and storage of information about gene and protein activity in order to identify toxic substances in the environment and those populations at the greatest risk of environmental diseases. The National Center for Toxicogenomics (NCT) was created to promote the evolution of gene and protein expression technologies and their use to understand adverse environmental effects on human health. To this end, the NCT will use toxicogenomics methods to measure gene and protein expression, applying the collective effort of many individuals and institutions to develop and populate a knowledge base on Chemical Effects in Biological Systems (CEBS). We envision that the information in the NCT knowledge base will be integrated with other toxicological, genomic and biological information to better understand environmental health risks. Thus, the promise of toxicogenomics is to build an unprecedented body of knowledge that can be used to guide future research, improve environmental health and aid in regulatory decision-making.

Table of Contents
Contents Executive Summary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Moving Beyond Classical Toxicology . . . . . . . . . . . . . . . . . . 4 Discovery vs. Hypothesis-Driven Science . . . . . . . . . . . . . . . 5 Program Goals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Technologies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Structure . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Academic Members of the TRC . . . . . . . . . . . . . . . . . . . . . 16 The Goals of the TRC . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Ethical, Legal and Social Implications (ELSI) . . . . . . . . . . . . 19 The Goals of the NCT . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Appendix . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 The Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30