World Health Organization : Year 1988 ; The Special Programme for Research and Training in Tropical Diseases, Filariasis Sc-Swg (83-88) Issue 88.3: Report of the Steering Committee of the Scientific Working Group on Filariasis

By World Health Organization

Book Id: WPLBN0000198039
Format Type: PDF eBook
File Size: 3.8 MB
Reproduction Date: 2005

Title:	World Health Organization : Year 1988 ; The Special Programme for Research and Training in Tropical Diseases, Filariasis Sc-Swg (83-88) Issue 88.3: Report of the Steering Committee of the Scientific Working Group on Filariasis
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Organization, W. H. (n.d.). World Health Organization : Year 1988 ; The Special Programme for Research and Training in Tropical Diseases, Filariasis Sc-Swg (83-88) Issue 88.3. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
I. POSITION STATEMENT During the current reporting period (July 1983 to June 1988) two WHO Expert Committees produced reports on the major diseases of concern to the FilariasXs Scientific Working Group (SWG) (B-81; B-83). As a result, updated estimate8 of the prevalence of both onchocerciasis and lymphatic filariasis have become available. Onchocerciasis is now considered endemic in 34 countries: in Africa ( 2 6 ) , Latin America (6) and the Eastern Mediterranean ( Z ) , where there are populations of 78 million, 5 million and 2 million, respectively, at risk. Presently, 17.6 million people are infected and ahouc 336 000 are blind due to onchocerciasis. 1,ymphatlc filariasis, on the other hand, is endemic over an even wider geographic area, coverlng tropical and subtropical Africa, Central and South America, Asia and Oceania. In these zones there are, collectively, an estimated 905 million people at risk, and over 90 million are believed to be infected.

Table of Contents
CONTENTS -Page 1. POSITIIJZ ST;:TEIKKNT . . . . . . . . . . . . . . . . . . . . . . . . s 2. RESEARCH TO IMPROVE DISEASE CONTROL . . . . . . . . . . . . . . . 4 2.1 Objectives . . . . . . . . . . . . . . . . . . . . . . . . 4 2.2 The operation of the SWF . . . . . . . . . . . . . . . . . . 5 7 . 9 Progress in Research and Development under the Plan . . . . . 6 2.3.1 Workplan . . . . . . . . . . . . . . . . . . . . . . . 6 2.3.2 Progress in general and responses to recomrncndations . 7 2.3.3 Highlights . . . . . . . . . . . . . . . . . . . . . 9 2.4 Detailed Progrese . . . . . . . . . . . . . . . . . . . 10 2 . 4 . 1 Immunological, pathological and molecular biological research . . . . . . . . . . . . . . . . . . 10 2.4.1.1 Immunodiagnosis and detection of parasite 2.4.1.2 Imamnutniogpeantsh ogen.es.is. a.nd.. p..at..ho..lo..py.. .......................... 1151 2.4.1.3 Protective immunity . . . . . . . . . . . . . . . . 19 2.4.1.4 Molecular biology 20 2.4.1.5 Work mainly outsidc the Programme . . . . . . . . 23 2.4.2 Chemothera~y . . . . . . . . . . . . . . . . . . . . . 27 research . . . . . . . . . . . . 28 . . . . I (a) Lead directed synthesis, of new compounds 28 (b) Parasite biochemistr.y,. m.et.ab.ol.is.m .an.d . . . . . . . related studies . . . . . . . . . . 28 (c) Anti-filarial drug screening 30 (. 2.4.2.2 Clinical trials . . . . . . . . . . . . . . . . . 35 (a) Trials within the Programme . . . . . . . . . . . 35