World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Ptr Drugs 89.3: Report of Prospective Thematic Review (PTR) on Directions and Organization of TDR’s Research and Development Related to Drugs

By World Health Organization

Book Id: WPLBN0000210076
Format Type: PDF eBook
File Size: 0.7 MB
Reproduction Date: 2005

Title:	World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Ptr Drugs 89.3: Report of Prospective Thematic Review (PTR) on Directions and Organization of TDR’s Research and Development Related to Drugs
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Organization, W. H. (n.d.). World Health Organization : Year 1989 ; The Special Programme for Research and Training in Tropical Diseases Ptr Drugs 89.3. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
INTRODUCTION The Special Programme for Research and Training in Tropical Diseases (TDR) was set up in 1977 with a mandate which includes the development of new and better technologies for the control of tropical diseases. In the twelve years of its existence, and wIth a modest budget ranging from US$ 20-30 million per annum, the TDR Programme has been associated with the development of over sixty such products. It has had a major impact on basic research, as judged both by scientific publications of research it has supported and by other criteria such an the number of parasite genes cloned. On the drug development side, it has done much to promote clinical work, especially regarding the standardization and vetting of protocols, post-registration field trials of drugs such as ivermectin, mefloquine and halofantrine and the evaluation of multidrug therapy for leprosy. It has tended, however, to leave preclinical development Co rho pharmaceutical industry and has not been directly involved in the drug distribution business. The former i s becoming an increarrlng problem with tho demise of the pharmaceutical industry's activities in thls area; the latter is a continuing problem. The purpose of Chis meeting, therefore, was to review the current situation with regard to consumer potential, drug distribution

Table of Contents
CONTENTS & 1 . TERMS OF REFERENCE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 2 . COMMENTS AND RECOMMENDATIONS OF STAC SUBCOMMITTEE . . . . . . . . . . . . . . . . 3 2.1 Drug Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2 . 2 Drug Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 9 REPORT OF THE MEETING 3 . INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 4 . DISEASE TARGETS AND POPULATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 4 . 1 Disease Targets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 4 . 2 Needs for New Drugs . . . . . . . . 5 4 . 3 Expenditure on Tropical Diseases 5 4 . 4 Consumer Potential 6 5 . DRUG PURCHASE AND DISTRIBUTION . . . . . . . . . . . . . . . . . . 1 2 OCT. 7990 7 5.1 Essential Drugs Programme 7 5 . 2 Role of UNICEF 7 5.3 Bilateral Agencies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 5.4 Private Sector . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 6 . REGISTRATION OF DRUGS FOR THE THIRD WORLD . . . . . . . . . . . . . . . . . . . . . . . . a 7 . ROLE OF DEVELOPING COUNTRIES IN DRUG DEVELOPMENT AND MANUFACTURE . 8 8 . RESEARCH AND DEVELOPMENT STRATEGIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 8.1 New Approaches . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 8.2 Drug Targets in Human Pharmacology as Leads . . . . . . . . . . . . . . . . . 9 8.3 Cross Disease Drug Targets . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 9 . MECHANISMS USED FOR DRUG DEVELOPMENT IN OTHER DISEASE AREAS WITH LIMITED FINANCIAL RETURN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10