World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, World Health Organization, Biological Blood, No. 70.1: Report of a Group of Consultants on Pusmapheresis and Immunizatxon of Donors

By World Health Organization

Book Id: WPLBN0000218003
Format Type: PDF eBook
File Size: 0.6 MB
Reproduction Date: 2005

Title:	World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, World Health Organization, Biological Blood, No. 70.1: Report of a Group of Consultants on Pusmapheresis and Immunizatxon of Donors
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Organization, W. H. (n.d.). World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, World Health Organization, Biological Blood, No. 70.1. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
In World Health Assembly r e s o l u t i o n wtiA28.72 concerning blood and blood products, t h e D i r e c t o r Gcneral was requested: . r r t h e rs t u d y t h e p r a c t i c e of commercial plasmapi>eresis including the h e a l t h hazards and e t h i c a l i m p l i c a t i o n s , p a r t i c u l a r l y i n developing c o u n t r i e s , and - t o take s t e p s t o develop good manufacturing p r z c t i c e s s p e c i a l l y f o r blood and blood components i n order t o p r o t e c t the h e a l t h of both donor and r e c i p i e n t s . In the implementation of t h e s e r e q u e s t s t h c I n t e r i i a t i o n a l Requirements f o r t h e C o l l e c t i o n , Processin25 and Quality Control oi: Human Blood were formulated during which a numher of problems were i d e n t i f i e d . One of these concerned the q u a n t i t y 01 plasma permitted t o be taken by plasmapheresis and another concerned the i m u n i e a t i o n 05 donors f o r t h e p r o v i s i o n of hyperimmune globulins. Accordingly, a Group of Consultants was convencd t o d i s c u s s t h e v a r i o u s i s s u e s concerned with plasmapheresis and t h e immunization of donors.

Table of Contents
CONTENTS INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 PUSMAPHERESIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1 . Definition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 2 . Donations by plasmapherfsis . . . . . . . . . . . . . . . . . . . . . . 4 3 . The e f f e c t s of plasmapheresis on plasma c o n s t i t u e n t s . . . . . . . . . . . . . . . 5 ( i ) Albumin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 ( i i ) Imunoglobulins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . S ( i i i ) Factors a f f e c t i n g coagulation . . . . . . . . . . . . . . . . . . . . . . . . 5 ( i v ) Lipoproteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 4 . Adverse r e a c t i o n s involved i n plasmapheresis procedures . . . . . . . . . . . . . 6 ( i ) Vasovagalsyncope . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 ( i i ) Haemolytic transfusion r e a c t i o n s . . . . . . . . . . . . . . . . . . . . . . 6 ( i i i ) Local i n f e c t i o n . i n f l a m a t i o n or haematoma a t phlebotomy s i t e . . . . . . . . 6 ( i v ) A l l e r g i c and anaphylactoid type r e a c t i o n s . . . . . . . . . . . . . . . . . . 7 (v) Reactions r e l a t e d to i m u n i z a t i o n . . . . . . . . . . . . . . . . . . . . . . 7 (vi) Systemic i n f e c t i o n from plasmapheresis . . . . . . . . . . . . . . . . . . . 7 5 . Recruitment and s e l e c t i o n of donors . . . . . . . . . . . . . . . . . . . . . . . 7 A . F i r s t time donors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 B . Donors who have been plasmapheresed previously . . . . . . . . . . . . . . . . . . 8 C . Plasmapheresis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 6 . C r i t e r i a for the acceptance of donors . . . . . . . . . . . . . . . . . . . . . . 9 A . Medical h i s t o r y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 (i) General . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 ( i i ) I n f e c t i o u s diseases . . . . . . . . . . . . . . . . . . . . . . 9 ( i i i ) pregnancy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 ( i v ) Minorsurgery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 (v) Xmunization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11