World Health Organization : Year 1990 ; The Special Programme for Research and Training in Tropical Diseases Immal, Tuberculosis 90.3: Report of a Meeting on Transmission-Blocking Immunity in Malaria

By World Health Organization

Book Id: WPLBN0000225948
Format Type: PDF eBook
File Size: 2.8 MB
Reproduction Date: 2005

Title:	World Health Organization : Year 1990 ; The Special Programme for Research and Training in Tropical Diseases Immal, Tuberculosis 90.3: Report of a Meeting on Transmission-Blocking Immunity in Malaria
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Organization, W. H. (n.d.). World Health Organization : Year 1990 ; The Special Programme for Research and Training in Tropical Diseases Immal, Tuberculosis 90.3. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
1. INTRODUCTION Research towards the development of malaria vaccines employs a strategy v n g h e identification and production of parasite antigens which specifically elicit protective immune responses in the human host. Antigens from several lifc-cycle stages of plasmodia are potential vaccine candidates. In the case of target antigens of transmisaion-blocking immunity, che immune response will limit transmfssion of infection by suppressing the development of rexusl and spor~~~onsitca ges. The rationale for transmission-blocking vaccine development rests on the expectation that such vaccines will reduce malnria transmission levels, at least under certain epidemiological conditions, and, if used in combinati.on w i t h sporozoite or asexual blood-stage vaccines, will prevent, the propagation of any vaccine-resistant mutant parasites.

Table of Contents
CONTENTS w,, INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 TARGET ANTIGENS OF TRANSMISSION-BLOCKING ANTIBODIES . . . . . . . . . . . . . . . . . . . . 2 : DEVELOPMENTAL ASPECTS OF SEXUAL STAGES AND GENERAL MECHANISMS OF TRANSMISSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 NATURALLY ACQUIRED TRANSMISSION-BLOCKING IMMUNITY IN HUMANS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .3.1 CLONING AND EXPRESSION OF SEXUAL STAGE ANTIGENS . . . . . . . . . . . . . . . . . . . . . . 42 QUANTITATIVE STUDIES (MATHEMATICAL MODELS): IMPACT OF IMMUNITY ON TRANSMISSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 VACCINES: DEVELOPMENTAL ISSUES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 CONCLUSIONS AND RECOMMENDATIONS FOR FURTHER STUDIES . . . . . . . . . . . . . . . . . . 71 LIST OF PARTICIPANTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .7