World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, Leishmaniasis, Working Paper, No. 72.1: Biological Cure and Immunity ; The Immune Response in Leishmaniasis

By J. Mauel

Book Id: WPLBN0000006433
Format Type: PDF eBook:
File Size: 0.2 MB
Reproduction Date: 2005

Title:	World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, Leishmaniasis, Working Paper, No. 72.1: Biological Cure and Immunity ; The Immune Response in Leishmaniasis
Author:	J. Mauel
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Mauel, B. J. (n.d.). World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, Leishmaniasis, Working Paper, No. 72.1. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
Presh normal serum from many animal species displays potent lytic activity against various Leishmania parasites, perhaps due to the occurrence of natural antibodies or to activation of complement by the alternative route. Parasite survlval within the host m y thus depend on the capacity of the microorganism to become intracellular. No particular organelle is detectable ultrastructurally that might facilitate cell invasion, and leishmaniae appear to be internalized by simple phagocytosis. Little is known regarding the nature of the molecular Ytructures mediating attachment of the parasites to the phagocytes. Receptors for the Fc portion of Fmunoglobulins or complement factors do nor appear to be involved and it is possib1.e thac parasites bind to macrophages via lectin-like structures on the host-Cells and appropriate ligands on the microorganism, or vice versa.

Table of Contents
CONTENTS -Page 1. Introduction.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1 Some features of the biology of Leishmania parasites that are relevant to host defence . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Genetic aspects of infection . . . . . . . . . . . . . . . . . . . . . . . . 2 2. IIuman leishrnaniasis: main Lmr~nological features . . . . . . . . . . . . . . . . 2 2.1 Cutaneous leishmaniasis . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.2 Visceral leishmaniasis . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 2.3 Mucocutaneous leishmaniasis . . . . . . . . . . . . . . . . . . . . . . . . . 4 2.4 Immune response and biological cure in human leishmaniasis . . . . . . . . . 4 3. Immunity in animal models . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3,1 The guinea-pig . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.2 The mouse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .4