Bulletin of the World Health Organization : 1993; Volume 71, Number 3-4, Year 1993 71 (3-4), Pages 361-366: Ivermectin Dose Assessment Without Weighing Scales

By N. D. E. Alexander

Book Id: WPLBN0000118520
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Reproduction Date: 2005

Title:	Bulletin of the World Health Organization : 1993; Volume 71, Number 3-4, Year 1993 71 (3-4), Pages 361-366: Ivermectin Dose Assessment Without Weighing Scales
Author:	N. D. E. Alexander
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago D. E. Alexande, B. N. (n.d.). Bulletin of the World Health Organization : 1993; Volume 71, Number 3-4, Year 1993 71 (3-4), Pages 361-366. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
This work, a review of some of the available Iiterature concerning the morphology, survival and culture of Treponerna pallidztnz and associated organisms, appears within some 60 years of the final definition of T. palliclrniz as the cause of syphilis by Schaudinn & Hoffmann in 1905, and only shortly after the death of Erich Hoffmann in May 1959 at the age of 92 years. The above remarks of Levaditi, made at the XIVth International Congress of Hygiene held in Berlin in 1907, at which Schaudinn and Hoffmann were being widely congratulated on their discovery of only two years before, are just as applicable today, more than half a century later. The intimate nature of the organism, and the key to its successful cultivation outside the bodies of men or animals with the retention of its essential characteristics (i.e., virulence), still remain to be determined.

Table of Contents
CONTENTS Page 1 . Introduction . . . . . . . . . . . . . . . . . . . . . . . . .5 2 . Taxonomy . . . . . . . . . . . . . . . . . . . . . . . . . .9 3 . Morphology: I . Methods of examination . . . . . . . . . . . .15 4 . Morphology: I1 . General characteristics (A) . . . . . . . . . . .21 5 . Morphology: I11 . General characteristics (B) . . . . . . . . . . .26 6. Life-cycle of treponemes: I . Division and round forms . . . . . .35 7. Life-cycle of treponemes: I1. Granular and invisible forms . . . . .41 8 . Culture of 7 . pallidurn in vitro: I . History . . . . . . . . . . . .47 9 . Culture of T . pallidurn in vitro: I1 . The cultured strains . . . . . .54 10 . Culture of T . pallidurn in vitro : I11 . Media . . . . . . . . . . . .60 11 . Culture of T . pallidurn in vitro: IV . Growth requirements . . . . .66 12 . Culture of T . pallidurn: V . Tissue and egg culture . . . . . . . . .73 13 . Survival of T . pallidurn outside the body: I . General observations.... .78 14 . Survival of T . pallidum outside the body: I1 . Factors favouring survival . . . . . . . . . . . . . . . . . . . . . . . . . .86 15 . In vivo culture of treponemes: I . Introduction . . . . . . . . . .91 16 . In vivo culture of treponemes: I1 . Syphilis in the rabbit . . . . . .94 17 . In vivo culture of treponemes: ILI . Other treponematoses in the rabbit 18 . In vivo culture of treponemes: IV . In other animals . . . . . . . .105 19 . Summary and conclusions . . . . . . . . . . . . . . . . . . .110 20 . RCsumC . . . . . . . . . . . . . . . . . . . . . . . . . . .118 21 . Cumulative list of references . . . . . . . . . . . . . . . . . .137