World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, World Health Organization Bvi, No. 73.14: Ad Hoc Working Group on Developments in Pertussis Vaccine

By World Health Organization

Book Id: WPLBN0000218008
Format Type: PDF eBook
File Size: 0.4 MB
Reproduction Date: 2005

Title:	World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, World Health Organization Bvi, No. 73.14: Ad Hoc Working Group on Developments in Pertussis Vaccine
Author:	World Health Organization
Volume:
Language:	English
Subject:	Health., Public health, Wellness programs
Collections:	Medical Library Collection, World Health Collection
Historic Publication Date:
Publisher:	World Health Organization


Citation APA MLA Chicago Organization, W. H. (n.d.). World Health Organization : Report on a European Syposium Convened by the Regional Office for Europe, World Health Organization Bvi, No. 73.14. Retrieved from http://gutenberg.cc/

Description
Medical Reference Publication

Excerpt
Whooping cough i c a d i s e a s e of world-wide d i s t r i b u t i o n . It causes s e r i o u s problems i n both the developed and developing c o u n t r i e s . Despite ample l i t e r a t u r e on p e r t u s s i s , l i t t l e i s r e a l l y know about the inicrobiology, epidemiology, prevention and treatment o f t h e d i s e a s e . Kecent research has r e s u l t e d in the i s o l a t i o n and c h a r a c t e r i z a t i o n of c e l l u l a r components from Bordetella p e r t u s s i s , but t h e i r r o l e , i n d i v i d u a l l y and c o l l e c t i v e l y , in pathogenesis or a$ p r o t e c t i v e a n t i g e n s , has not been e l u c i d a t e d . T h i s l a c k o f basic knowledge of the d i s e a s e , its d i a g n o s i s , the e t i o l o g i c agent and the s i g n i f i c a n t p r o t e c t i v e intnlunc response has complicate0 the development or an improved vaccine.

Table of Contents
Listofparticipants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2. Present situation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 3. Recent research on pertussis vaccine . . . . . . . , . . . . , , . . . . . . 6 b . Control tests suggested for pertussis vaccines . . . . . . . . . . . . . . . 8 5. Clinical testing of candidate vaccines . . . . . . . . . . . . . . . . . . . 9 6. Standardization and control of new vaccines . . . . . . . . . . . . . . . . . 10 7. Researchneeds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 7.1 Immune mechanisms and protective antigens . . . . . . . . . . . . . . . 10 7.1.1 Identification of protective antigens . . . . . . . . . . . . . 10 7.1.2 Genetics and Molecular Biology of B.pertussis . . . . . . . . . 10 7.1.3 Measurement of Antibody Responses . . . . . . . . . . . . . . . 11 7.2 Mucosal Imunity . . . . . . . . . . . . . . . . . . . . . . . . . . . I I 7.2.1 Methods to measure mucosal imunity . . . . . . . . . . . . . . 11 7.2.2 Methods of stimulating mucosal immunity . . . . . . . . . . . . 11 7.3 Development of animal models . . . . . . . . . . . . . . . . . . . . . 11 Annex. Proposal for a collaborative study with Japanese acellular DPT vaccine . . 12