Plos One : Combination Therapy Using Monoclonal Antibodies Against Respiratory Syncytial Virus Rsv G Glycoprotein Protects from Rsv Disease in Balb, Volume 7

By Varga, Steven, M.

Book Id: WPLBN0003935249
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title:	Plos One : Combination Therapy Using Monoclonal Antibodies Against Respiratory Syncytial Virus Rsv G Glycoprotein Protects from Rsv Disease in Balb, Volume 7
Author:	Varga, Steven, M.
Volume:	Volume 7
Language:	English
Subject:	Journals, Science, Medical Science
Collections:	Periodicals: Journal and Magazine Collection (Contemporary)
Historic Publication Date:
Publisher:	Plos


Citation APA MLA Chicago Varga, S. M. (n.d.). Plos One : Combination Therapy Using Monoclonal Antibodies Against Respiratory Syncytial Virus Rsv G Glycoprotein Protects from Rsv Disease in Balb, Volume 7. Retrieved from https://gutenberg.cc/

Description
Description : Therapeutic options to control respiratory syncytial virus (RSV) are limited, thus development of new therapeutics is high priority. Previous studies with a monoclonal antibody (mAb) reactive to an epitope proximal to the central conserved region (CCR) of RSV G protein (mAb 131-2G) showed therapeutic efficacy for reducing pulmonary inflammation RSV infection in BALB/c mice. Here, we show a protective effect in RSV-infected mice therapeutically treated with a mAb (130-6D) reactive to an epitope within the CCR of G protein, while treatment with a mAb specific for a carboxyl G protein epitope had no effect. Combined treatment with mAbs 130-6D and 131-2G significantly decreased RSV-associated pulmonary inflammation compared to either antibody alone. The results suggest that anti-RSV G protein mAbs that react at or near the CCR and can block RSV G protein-mediated activities are effective at preventing RSV disease and may be an effective strategy for RSV therapeutic treatment.





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